The Effect of Carbon Tetrachloride Poisoning on Subcellular Metal Distribution in Rat Liver

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The effect of carbon tetrachloride poisoning on subcellular metal distribution in rat liver.

The mechanism by which the ingestion of carbon tetrachloride results in distinct and reproducible histological alterations of the liver has been investigated intensively, both in &JO and in vitro (3-11). The mitochondria of liver cells are particularly vulnerable to this lipid solvent, as shown by their increased permeability (3), decreased coenzyme content (7, 8), and the loss of their ability...

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15 صفحه اول

The Effect of Benzpyrene, Phénobarbital,and Carbon Tetrachloride on Subcellular Metal Distribution and Microsomal Enzyme Activity

Alterations in the normal subcellular metal distribution of rat liver and lung have been produced by the acute administration of phénobarbital, carbon tetrachloride, and intratracheal 3,4-benzpyrene. Following the isolation of the various subcellular fractions by a standard technique, the metal composition of the subfractions was determined by atomic absorption spectrophotometry and expressed ...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1960

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)69377-9